human VEGFC shRNA silencing AAV

Name
AAV-h-VEGFC-shRNA

Cat No
shAAV-227459

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human VEGFC.

shAAV-227459

AAV-h-VEGFC-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human VEGFC (vascular endothelial growth factor C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Flt4-L; LMPH1D; VRP

Description (Vector)

VEGFC is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family, is active in angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-3 receptors. Only the fully processed form can bind and activate VEGFR-2 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor D.

Gene ID

7424

Gene Name (Vector)

vascular endothelial growth factor C

Gene Symbol

VEGFC

HGNC ID

HGNC:12682

ORF Size (aa)

1260

RefSeq ID

NM_005429

RefSeq Synonyms

NM_005429, BC063685, BC035212,

Species

human

UniGene ID

Hs.435215

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.