human VDAC3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human VDAC3.
shAAV-227455
AAV-h-VDAC3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human VDAC3 (voltage dependent anion channel 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
HD-VDAC3; VDAC-3
Description (Vector)
VDAC3 encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene.
Gene ID
7419
Gene Name (Vector)
voltage dependent anion channel 3
Gene Symbol
VDAC3
HGNC ID
HGNC:12674
ORF Size (aa)
852
RefSeq ID
NM_005662
RefSeq Synonyms
NM_005662, NM_001135694, BC056870,
Species
human
UniGene ID
Hs.699301
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.