human USP8 shRNA silencing AAV

Name
AAV-h-USP8-shRNA

Cat No
shAAV-227347

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human USP8.

shAAV-227347

AAV-h-USP8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human USP8 (ubiquitin specific peptidase 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

80

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

deubiquitinating enzyme 8; hUBPy; HumORF8; PITA4; SPG59; ubiquitin carboxyl-terminal hydrolase 8; ubiquitin isopeptidase Y; Ubiquitin thioesterase 8; ubiquitin thiolesterase 8; ubiquitin-specific-processing protease 8; UBPY

Description (eCommerce)

USP8 (ubiquitin-specific processing protease 8) is also known as UBPY (ubiquitin isopeptidase Y). USP8 is a hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P40818].

Gene ID

9101

Gene Name (eCommerce)

ubiquitin specific peptidase 8

Gene Name (Vector)

ubiquitin specific peptidase 8

Gene Symbol

USP8

HGNC ID

HGNC:12631

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3357

ORF Size (bp)

3357 bp

Protein Name (eCommerce)

Ubiquitin carboxyl-terminal hydrolase 8

RefSeq ID

NM_005154

RefSeq Synonyms

NM_005154, NM_001283049, NM_001128611, NM_001128610, BC110590,

Research Areas

Cell Cycle,EGFR Signaling,Signal Transduction,Ubiquitination

Research Areas (Faceted)

signal_transduction,cell_biology,cell_cycle,genetics

Species

human

Target Sentence

USP8 (ubiquitin-specific processing protease 8) is also known as UBPY (ubiquitin isopeptidase Y). USP8 is a hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ P40818].

UniGene ID

Hs.644563

UniProt ID (eCommerce)

P40818

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.