human USP2 shRNA silencing AAV

Name
AAV-h-USP2-shRNA

Cat No
shAAV-227292

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human USP2.

shAAV-227292

AAV-h-USP2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human USP2 (ubiquitin specific peptidase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

UBP41; USP9

Description (Vector)

USP2 encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene ID

9099

Gene Name (Vector)

ubiquitin specific peptidase 2

Gene Symbol

USP2

HGNC ID

HGNC:12618

ORF Size (aa)

1089

RefSeq ID

NM_004205

RefSeq Synonyms

NM_171997, NM_004205, NM_001243759, BC041366, BC002955, BC002854,

Species

human

UniGene ID

Hs.524085

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.