human USP10 shRNA silencing AAV

Name 
AAV-h-USP10-shRNA
Cat No 
shAAV-227282
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human USP10.

shAAV-227282
AAV-h-USP10-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human USP10 (ubiquitin specific peptidase 10). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
deubiquitinating enzyme 10; ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific protease 10; ubiquitin thioesterase 10; ubiquitin thiolesterase 10; ubiquitin-specific-processing protease 10; UBPO
Description (eCommerce)
Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 10 (USP10) is a member of this family that has been found to interact with Ras-GTPase activating protein (G3BP).
Description (Vector)
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene.
Gene ID
9100
Gene Name (eCommerce)
ubiquitin specific peptidase 10
Gene Name (Vector)
ubiquitin specific peptidase 10
Gene Symbol
USP10
HGNC ID
HGNC:12608
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2397
ORF Size (bp)
2397 bp
Protein Name (eCommerce)
Ubiquitin carboxyl-terminal hydrolase 10
RefSeq ID
NM_005153
RefSeq Synonyms
NM_005153, NM_001272075, BC000263,
Research Areas
Autophagy,Cytoskeleton,DNA Damage/Repair,Ubiquitination
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Ubiquitin (Ub) is a highly conserved protein found ubiquitously in eukaryotic organisms. The conjugation of ubiquitin to proteins is an important means to regulate protein activity for many cellular processes by tagging them for degradation. Removal of Ub can rescue proteins from degradation. This is accomplished by the ubiquitin-specific processing protease (UBP) family of enzymes. Ubiquitin specific processing protease 10 (USP10) is a member of this family that has been found to interact with Ras-GTPase activating protein (G3BP).
UniGene ID
Hs.136778
UniProt ID (eCommerce)
Q14694

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.