human UNC13D shRNA silencing AAV

Name
AAV-h-UNC13D-shRNA

Cat No
shAAV-227185

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human UNC13D.

shAAV-227185

AAV-h-UNC13D-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UNC13D (unc-13 homolog D). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

FHL3; HLH3; HPLH3; Munc13-4

Description (Vector)

UNC13D encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.

Gene ID

201294

Gene Name (Vector)

unc-13 homolog D

Gene Symbol

UNC13D

HGNC ID

HGNC:23147

ORF Size (aa)

3273

ORF Size (bp)

3273 bp

RefSeq ID

NM_199242

RefSeq Synonyms

NM_199242, BC067084,

Species

human

UniGene ID

Hs.41045

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.