human UBE2L6 shRNA silencing AAV

Name
AAV-h-UBE2L6-shRNA

Cat No
shAAV-227023

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human UBE2L6.

shAAV-227023

AAV-h-UBE2L6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UBE2L6 (ubiquitin conjugating enzyme E2 L6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

RIG-B; UBCH8

Description (Vector)

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Gene ID

9246

Gene Name (Vector)

ubiquitin conjugating enzyme E2 L6

Gene Symbol

UBE2L6

HGNC ID

HGNC:12490

ORF Size (aa)

462

RefSeq ID

NM_004223

RefSeq Synonyms

NM_198183, NM_004223, BC032491,

Species

human

UniGene ID

Hs.425777

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.