human UBAC1 shRNA silencing AAV

Name
AAV-h-UBAC1-shRNA

Cat No
shAAV-226969

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human UBAC1.

shAAV-226969

AAV-h-UBAC1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UBAC1 (UBA domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

E3 ubiquitin-protein ligase subunit KPC2; GBDR1; glialblastoma cell differentiation-related protein 1; kip1 ubiquitination-promoting complex protein 2; Kip1 ubiquitination-promoting complex subunit 2; KPC2; putative glialblastoma cell differentiation-related protein; testicular secretory protein Li 64; UBA domain-containing protein 1; UBADC1; ubiquitin associated domain containing 1; ubiquitin-associated domain-containing protein 1

Description (eCommerce)

UBA domain containing 1 (UBAC1) is a non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. UBAC1 is required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BSL1].

Gene ID

10422

Gene Name (eCommerce)

UBA domain containing 1

Gene Name (Vector)

UBA domain containing 1

Gene Symbol

UBAC1

HGNC ID

HGNC:30221

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1218

ORF Size (bp)

1218 bp

Protein Name (eCommerce)

Ubiquitin-associated domain-containing protein 1

RefSeq ID

NM_016172

RefSeq Synonyms

NM_016172, BC011822, BC004967,

Research Areas

Golgi Apparatus,Ubiquitination

Research Areas (Faceted)

cell_biology

Species

human

Target Sentence

UBA domain containing 1 (UBAC1) is a non-catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. UBAC1 is required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BSL1].

UniGene ID

Hs.9194

UniProt ID (eCommerce)

Q9BSL1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.