human TWIST1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TWIST1.
shAAV-226880
AAV-h-TWIST1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TWIST1 (twist family bHLH transcription factor 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ACS3; B-HLH DNA binding protein; bHLHa38; BPES2; BPES3; class A basic helix-loop-helix protein 38; CRS; CRS1; CSO; H-twist; SCS; SWCOS; TWIST; twist basic helix-loop-helix transcription factor 1; twist homolog 1; TWIST homolog of drosophila; twist-related protein 1
Description (eCommerce)
TWIST1 is a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. TWIST1 forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. TWIST1 may also regulate neural tube closure, limb development and brown fat metabolism. The TWIST1 gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. [taken from NCBI Entrez Gene (Gene ID: 7291)].
Description (Vector)
Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. The protein encoded by this gene is a bHLH transcription factor and shares similarity with another bHLH transcription factor, Dermo1. The strongest expression of this mRNA is in placental tissue; in adults, mesodermally derived tissues express this mRNA preferentially. Mutations in this gene have been found in patients with Saethre-Chotzen syndrome.
Gene ID
7291
Gene Name (eCommerce)
twist family bHLH transcription factor 1
Gene Name (Vector)
twist family bHLH transcription factor 1
Gene Symbol
TWIST1
HGNC ID
HGNC:12428
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
609
ORF Size (bp)
609 bp
Protein Name (eCommerce)
Twist-related protein 1
RefSeq ID
NM_000474
RefSeq Synonyms
NM_000474, BC036704,
Research Areas
Angiogenesis,Apoptosis,Cancer,Cardiac Development,Cardiology,Cardiovascular,DNA Damage/Repair,EGFR Signaling,Gene Expression,Histone Modification,Hypoxia,Neurobiology,Neurodevelopment,RNA Binding,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,genetics,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
TWIST1 is a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. TWIST1 forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. TWIST1 may also regulate neural tube closure, limb development and brown fat metabolism. The TWIST1 gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. [taken from NCBI Entrez Gene (Gene ID: 7291)].
UniGene ID
Hs.66744
UniProt ID (eCommerce)
Q15672
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.