human TTF2 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TTF2.
shAAV-226735
AAV-h-TTF2-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TTF2 (transcription termination factor 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
F2; HuF2; human factor 2; lodestar homolog; lodestar protein; RNA polymerase II termination factor; transcription release factor 2; transcription termination factor 2; transcription termination factor, RNA polymerase II; ZGRF6; zinc finger, GRF-type containing 6
Description (eCommerce)
Transcription termination factor (TTF2) is a double-stranded DNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. TTF2 may contribute to mitotic transcriptional repression and may also be involved in pre-mRNA splicing [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UNY4].
Description (Vector)
TTF2 encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.
Gene ID
8458
Gene Name (eCommerce)
transcription termination factor 2
Gene Name (Vector)
transcription termination factor 2
Gene Symbol
TTF2
HGNC ID
HGNC:12398
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2031
ORF Size (bp)
2031 bp
Protein Name (eCommerce)
Transcription termination factor 2
RefSeq ID
NM_003594
RefSeq Synonyms
NM_003594, BC030058,
Research Areas
Gene Expression,Helicase Activity,mRNA Processing,mRNA Splicing,RNA Processing,Signal Transduction,Spliceosome,Transcription Factor/Regulator,TSH Signaling
Research Areas (Faceted)
signal_transduction,genetics,transcription_translation,cell_biology,genetics,signal_transduction
Species
human
Target Sentence
Transcription termination factor (TTF2) is a double-stranded DNA-dependent ATPase which acts as a transcription termination factor by coupling ATP hydrolysis with removal of RNA polymerase II from the DNA template. TTF2 may contribute to mitotic transcriptional repression and may also be involved in pre-mRNA splicing [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9UNY4].
UniGene ID
Hs.486818
UniProt ID (eCommerce)
Q9UNY4
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.