human TSSC4 shRNA silencing AAV

Name
AAV-h-TSSC4-shRNA

Cat No
shAAV-226666

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human TSSC4.

shAAV-226666

AAV-h-TSSC4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TSSC4 (tumor suppressing subtransferable candidate 4). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

TSSC4 is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. TSSC4 is located among several imprinted genes; however, this gene, as well as the pan-hematopoietic expression gene (PHEMX), escapes imprinting. TSSC4 may play a role in malignancies and disease that involve this region.

Gene ID

10078

Gene Name (Vector)

tumor suppressing subtransferable candidate 4

Gene Symbol

TSSC4

HGNC ID

HGNC:12386

ORF Size (aa)

798

RefSeq ID

NM_005706

RefSeq Synonyms

NM_005706, NM_001297661, NM_001297660, NM_001297659, NM_001297658, BC050616, BC006091,

Species

human

UniGene ID

Hs.523424

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.