human TRIM24 shRNA silencing AAV

Name
AAV-h-TRIM24-shRNA

Cat No
shAAV-226414

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human TRIM24.

shAAV-226414

AAV-h-TRIM24-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TRIM24 (tripartite motif containing 24). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

E3 ubiquitin-protein ligase TRIM24; hTIF1; PTC6; RING finger protein 82; RING-type E3 ubiquitin transferase TIF1-alpha; RNF82; TF1A; TIF1; TIF1A; TIF1ALPHA; TIF1-alpha; transcription intermediary factor 1-alpha; transcriptional intermediary factor 1; Tripartite motif-containing protein 24

Description (eCommerce)

TIF1 Alpha/TRIM24 is a member of a family of proteins that control transcription and chromatin remodeling through their interaction with transcription factors. The family of TIF1s (transcriptional intermediary factor 1) includes TIF1-alpha, TIF1-beta, and TIF1-gamma. TIF1-alpha plays an important role in development and mediates transcriptional control by interacting with the AF2 region of nuclear receptors such as estrogen, retinoic acid, and vitamin D3 receptors. TIF1-alpha has been shown to be a repressor of transcription. This transcriptional repression involves histone deacetylation and interaction with members of the heterochromatin protein 1 family.

Description (Vector)

TRIM24 mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene ID

8805

Gene Name (eCommerce)

tripartite motif containing 24

Gene Name (Vector)

tripartite motif containing 24

Gene Symbol

TRIM24

HGNC ID

HGNC:11812

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3153

ORF Size (bp)

3153 bp

Protein Name (eCommerce)

Transcription intermediary factor 1-alpha

RefSeq ID

NM_003852

RefSeq Synonyms

NM_015905, NM_003852, BC028689,

Research Areas

Apoptosis,Cancer,EGFR Signaling,Estrogen Signaling,FGF Signaling,Gene Expression,Host-Virus Interactions,Nuclear Receptor Coactivators,Signal Transduction,Transcription Factor/Regulator,Translational Control,Tumor Suppressors/Oncoproteins,Zinc-finger

Research Areas (Faceted)

cancer,cell_biology,infectious_disease,signal_transduction,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.490287

UniProt ID (eCommerce)

O15164

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.