human TPO shRNA silencing AAV

Name
AAV-h-TPO-shRNA

Cat No
shAAV-226282

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human TPO.

shAAV-226282

AAV-h-TPO-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TPO (thyroid peroxidase). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MSA; TDH2A; TPX

Description (Vector)

TPO encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.

Gene ID

7173

Gene Name (Vector)

thyroid peroxidase

Gene Symbol

TPO

HGNC ID

HGNC:12015

ORF Size (aa)

2802

ORF Size (bp)

2802 bp

RefSeq ID

NM_000547

RefSeq Synonyms

NM_175722, NM_175721, NM_175719, NM_001206745, NM_001206744, NM_000547, BC095448, BC063107,

Species

human

UniGene ID

Hs.467554

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.