human TNFSF10 shRNA silencing AAV

Name
AAV-h-TNFSF10-shRNA

Cat No
shAAV-226096

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human TNFSF10.

shAAV-226096

AAV-h-TNFSF10-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TNFSF10 (tumor necrosis factor superfamily member 10). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Apo-2L; APO2L; CD253; TL2; TNLG6A; TRAIL

Description (Vector)

TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

8743

Gene Name (Vector)

tumor necrosis factor superfamily member 10

Gene Symbol

TNFSF10

HGNC ID

HGNC:11925

ORF Size (aa)

846

RefSeq ID

NM_003810

RefSeq Synonyms

NM_003810, NM_001190943, NM_001190942, BC032722,

Species

human

UniGene ID

Hs.478275

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.