human TNFRSF1A shRNA silencing AAV

Name
AAV-h-TNFRSF1A-shRNA

Cat No
shAAV-226085

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human TNFRSF1A.

shAAV-226085

AAV-h-TNFRSF1A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TNFRSF1A (TNF receptor superfamily member 1A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD120a; FPF; p55; p55-R; p60; TBP1; TNF-R; TNF-R-I; TNF-R55; TNFAR; TNFR1; TNFR55; TNFR60

Description (Vector)

TNFRSF1A is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.

Gene ID

7132

Gene Name (Vector)

TNF receptor superfamily member 1A

Gene Symbol

TNFRSF1A

HGNC ID

HGNC:11916

ORF Size (aa)

1368

ORF Size (bp)

1368 bp

RefSeq ID

NM_001065

RefSeq Synonyms

NM_001346092, NM_001346091, NM_001065, BC010140,

Species

human

UniGene ID

Hs.713833

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.