human TMPRSS2 shRNA silencing AAV

Name 
AAV-h-TMPRSS2-shRNA
Cat No 
shAAV-226012
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TMPRSS2.

shAAV-226012
AAV-h-TMPRSS2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TMPRSS2 (transmembrane protease, serine 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
PP9284; PRSS10
Description (Vector)
TMPRSS2 encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. TMPRSS2 was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
7113
Gene Name (Vector)
transmembrane protease, serine 2
Gene Symbol
TMPRSS2
HGNC ID
HGNC:11876
ORF Size (aa)
1479
ORF Size (bp)
1479 bp
RefSeq ID
NM_005656
RefSeq Synonyms
NM_005656, NM_001135099, BC051839,
Species
human
UniGene ID
Hs.439309

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.