human TMC8 shRNA silencing AAV

Name
AAV-h-TMC8-shRNA

Cat No
shAAV-225659

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human TMC8.

shAAV-225659

AAV-h-TMC8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TMC8 (transmembrane channel like 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

EV2; EVER2; EVIN2

Description (Vector)

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.

Gene ID

147138

Gene Name (Vector)

transmembrane channel like 8

Gene Symbol

TMC8

HGNC ID

HGNC:20474

ORF Size (aa)

2181

ORF Size (bp)

2181 bp

RefSeq ID

NM_152468

RefSeq Synonyms

NM_152468, BC141865, BC110296,

Species

human

UniGene ID

Hs.592102

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.