human TLR2 shRNA silencing AAV

Name
AAV-h-TLR2-shRNA

Cat No
shAAV-225587

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human TLR2.

shAAV-225587

AAV-h-TLR2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TLR2 (toll like receptor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD282; TIL4

Description (Vector)

TLR2 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.

Gene ID

7097

Gene Name (Vector)

toll like receptor 2

Gene Symbol

TLR2

HGNC ID

HGNC:11848

ORF Size (aa)

2355

ORF Size (bp)

2355 bp

RefSeq ID

NM_003264

RefSeq Synonyms

NM_003264, NM_001318796, NM_001318795, NM_001318793, NM_001318791, NM_001318790, NM_001318789, NM_001318787, BC033756,

Species

human

UniGene ID

Hs.519033

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.