human TK1 shRNA silencing AAV

Name
AAV-h-TK1-shRNA

Cat No
shAAV-225548

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human TK1.

shAAV-225548

AAV-h-TK1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TK1 (thymidine kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

epididymis secretory sperm binding protein; thymidine kinase 1 soluble isoform; thymidine kinase, cytosolic; TK2

Description (eCommerce)

Thymidine kinase 1 (TK1) catalyzes the phosphorylation of thymidine to maintain dTTP in the cell for DNA replication and repair. The salvage of thymidine by TK1 is cell-cycle regulated and important to genomic stability. TK1 is a phosphoprotein and exists in a dimeric or tetrameric form. Phosphorylation of TK1 may be important to its quaternary structure and the regulation of its catalytic activity.

Gene ID

7083

Gene Name (eCommerce)

thymidine kinase 1

Gene Name (Vector)

thymidine kinase 1

Gene Symbol

TK1

HGNC ID

HGNC:11830

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

705

ORF Size (bp)

705 bp

Protein Name (eCommerce)

Thymidine kinase, cytosolic

RefSeq ID

NM_003258

RefSeq Synonyms

NM_003258, NM_001346663, BC007986, BC007872, BC006484,

Research Areas

DNA Replication,Kinase/Phosphatase,Metabolism/Metabolic Process

Research Areas (Faceted)

cell_biology,genetics,metabolism,signal_transduction,transcription_translation

Species

human

Target Sentence

Thymidine kinase 1 (TK1) catalyzes the phosphorylation of thymidine to maintain dTTP in the cell for DNA replication and repair. The salvage of thymidine by TK1 is cell-cycle regulated and important to genomic stability. TK1 is a phosphoprotein and exists in a dimeric or tetrameric form. Phosphorylation of TK1 may be important to its quaternary structure and the regulation of its catalytic activity.

UniGene ID

Hs.515122

UniProt ID (eCommerce)

P04183

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.