human TJP1 shRNA silencing AAV

Name 
AAV-h-TJP1-shRNA
Cat No 
shAAV-225545
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human TJP1.

shAAV-225545
AAV-h-TJP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TJP1 (tight junction protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Tight junction protein 1; tight junction protein ZO-1; ZO-1; zona occludens 1; Zona occludens protein 1; zonula occludens 1 protein; Zonula occludens protein 1
Description (eCommerce)
TJP1 / ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. TJP1 / ZO-1 may be involved in signal transduction at cell-cell junctions [taken from NCBI Entrez Gene (Gene ID: 7082)].
Description (Vector)
TJP1 encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for this gene.
Gene ID
7082
Gene Name (eCommerce)
tight junction protein 1
Gene Name (Vector)
tight junction protein 1
Gene Symbol
TJP1
HGNC ID
HGNC:11827
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5247
ORF Size (bp)
5247 bp
Protein Name (eCommerce)
Tight junction protein ZO-1
RefSeq ID
NM_175610
RefSeq Synonyms
NM_175610, NM_003257, NM_001330239, NM_001301026, NM_001301025, BC111712,
Research Areas
Apoptosis,Hippo Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
TJP1 / ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. TJP1 / ZO-1 may be involved in signal transduction at cell-cell junctions [taken from NCBI Entrez Gene (Gene ID: 7082)].
UniGene ID
Hs.510833
UniProt ID (eCommerce)
Q07157

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.