human TGIF2 shRNA silencing AAV

Name
AAV-h-TGIF2-shRNA

Cat No
shAAV-225395

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human TGIF2.

shAAV-225395

AAV-h-TGIF2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TGIF2 (TGFB induced factor homeobox 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

TGIF2 is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene.

Gene ID

60436

Gene Name (Vector)

TGFB induced factor homeobox 2

Gene Symbol

TGIF2

HGNC ID

HGNC:15764

ORF Size (aa)

714

RefSeq ID

NM_021809

RefSeq Synonyms

NM_021809, NM_001199515, NM_001199514, NM_001199513, BC012816, BC006549,

Species

human

UniGene ID

Hs.632264

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.