human TES shRNA silencing AAV

Name
AAV-h-TES-shRNA

Cat No
shAAV-225314

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human TES.

shAAV-225314

AAV-h-TES-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TES (testin LIM domain protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

TESS; TESS-2

Description (Vector)

Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.

Gene ID

26136

Gene Name (Vector)

testin LIM domain protein

Gene Symbol

TES

HGNC ID

HGNC:14620

ORF Size (aa)

1266

ORF Size (bp)

1266 bp

RefSeq ID

NM_015641

RefSeq Synonyms

NM_152829, NM_015641, BC001451,

Species

human

UniGene ID

Hs.664957

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.