human TCIRG1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human TCIRG1.
shAAV-225225
AAV-h-TCIRG1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human TCIRG1 (T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
a3; Atp6i; ATP6N1C; ATP6V0A3; OC-116kDa; OC116; OPTB1; Stv1; TIRC7; Vph1
Description (Vector)
Through alternate splicing, this gene encodes two proteins with similarity to subunits of the vacuolar ATPase (V-ATPase) but the encoded proteins seem to have different functions. V-ATPase is a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. Mutations in this gene are associated with infantile malignant osteopetrosis.
Gene ID
10312
Gene Name (Vector)
T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3
Gene Symbol
TCIRG1
HGNC ID
HGNC:11647
ORF Size (aa)
2493
ORF Size (bp)
2493 bp
RefSeq ID
NM_006019
RefSeq Synonyms
NM_006053, NM_006019, BC032465, BC018133,
Species
human
UniGene ID
Hs.495985
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.