human TBXAS1 shRNA silencing AAV

Name
AAV-h-TBXAS1-shRNA

Cat No
shAAV-225170

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human TBXAS1.

shAAV-225170

AAV-h-TBXAS1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TBXAS1 (thromboxane A synthase 1). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS

Description (Vector)

TBXAS1 encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

6916

Gene Name (Vector)

thromboxane A synthase 1

Gene Symbol

TBXAS1

HGNC ID

HGNC:11609

ORF Size (aa)

1605

ORF Size (bp)

1605 bp

RefSeq ID

NM_001061

RefSeq Synonyms

NM_030984, NM_001314028, NM_001166254, NM_001166253, NM_001130966, NM_001061, BC041157, BC014117,

Species

human

UniGene ID

Hs.520757

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.