human TAP1 shRNA silencing AAV

Name
AAV-h-TAP1-shRNA

Cat No
shAAV-224966

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human TAP1.

shAAV-224966

AAV-h-TAP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TAP1 (transporter 1, ATP binding cassette subfamily B member). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ABC17; ABCB2; APT1; D6S114E; PSF-1; PSF1; RING4; TAP1*0102N; TAP1N

Description (Vector)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease.

Gene ID

6890

Gene Name (Vector)

transporter 1, ATP binding cassette subfamily B member

Gene Symbol

TAP1

HGNC ID

HGNC:43

ORF Size (aa)

2427

ORF Size (bp)

2427 bp

RefSeq ID

NM_000593

RefSeq Synonyms

NM_001292022, NM_000593, BC014081,

Species

human

UniGene ID

Hs.352018

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.