human TANK shRNA silencing AAV

Name
AAV-h-TANK-shRNA

Cat No
shAAV-224956

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human TANK.

shAAV-224956

AAV-h-TANK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human TANK (TRAF family member associated NFKB activator). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

I-TRAF; ITRAF; TRAF2

Description (Vector)

The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, the protein encoded by this gene can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

10010

Gene Name (Vector)

TRAF family member associated NFKB activator

Gene Symbol

TANK

HGNC ID

HGNC:11562

ORF Size (aa)

1278

ORF Size (bp)

1278 bp

RefSeq ID

NM_004180

RefSeq Synonyms

NM_133484, NM_004180, NM_001199135, BC067779, BC003388,

Species

human

UniGene ID

Hs.132257

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.