human SUZ12 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SUZ12.
shAAV-224778
AAV-h-SUZ12-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SUZ12 (SUZ12 polycomb repressive complex 2 subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
chET 9 protein; CHET9; chromatin precipitated E2F target 9 protein; JJAZ1; joined to JAZF1 protein; polycomb protein SUZ12; suppressor of zeste 12 protein homolog
Description (eCommerce)
SUZ12 (suppressor of zeste 12) is the human homolog of the drosophila SUZ12 gene. SUZ12 is a Polycomb group (PcG) protein and a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. A chromosomal aberration, t(7;17)(p15;q21), involving SUZ12 and JAZF1 may be a cause of endometrial stromal tumors. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15022].
Description (Vector)
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region.
Gene ID
23512
Gene Name (eCommerce)
SUZ12, polycomb repressive complex 2 subunit
Gene Name (Vector)
SUZ12 polycomb repressive complex 2 subunit
Gene Symbol
SUZ12
HGNC ID
HGNC:17101
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2220
ORF Size (bp)
2220 bp
Protein Name (eCommerce)
Polycomb protein SUZ12
RefSeq ID
NM_015355
RefSeq Synonyms
NM_015355, NM_001321207, BC015704,
Research Areas
Cancer,Chromatin Remodeling,Complexome,Epigenetic Regulation of Gene Expression,Histone Modification,Polycomb Proteins,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
SUZ12 (suppressor of zeste 12) is the human homolog of the drosophila SUZ12 gene. SUZ12 is a Polycomb group (PcG) protein and a component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. A chromosomal aberration, t(7;17)(p15;q21), involving SUZ12 and JAZF1 may be a cause of endometrial stromal tumors. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is frequently found in all cases of endometrial stromal tumors, except in endometrial stromal sarcomas, where it is rarer [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15022].
UniGene ID
Hs.462732
UniProt ID (eCommerce)
Q15022
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.