human SUMO4 shRNA silencing AAV

Name 
AAV-h-SUMO4-shRNA
Cat No 
shAAV-224746
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SUMO4.

shAAV-224746
AAV-h-SUMO4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SUMO4 (small ubiquitin-like modifier 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
dJ281H8.4; IDDM5; SMT3H4; SUMO-4
Description (Vector)
SUMO4 is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.
Gene ID
387082
Gene Name (Vector)
small ubiquitin-like modifier 4
Gene Symbol
SUMO4
HGNC ID
HGNC:21181
ORF Size (aa)
288
RefSeq ID
NM_001002255
RefSeq Synonyms
NM_001002255, BC130305,
Species
human
UniGene ID
Hs.657168

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.