human STXBP1 shRNA silencing AAV

Name
AAV-h-STXBP1-shRNA

Cat No
shAAV-224672

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human STXBP1.

shAAV-224672

AAV-h-STXBP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human STXBP1 (syntaxin binding protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

MUNC18-1; neuronal SEC1; NSEC1; N-Sec1; P67; protein unc-18 homolog 1; protein unc-18 homolog A; RBSEC1; syntaxin-binding protein 1; UNC18; unc18-1; unc-18A

Description (eCommerce)

Syntaxin-binding protein 1 (STXBP1) is a syntaxin-binding protein. STXBP1 appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor [taken from NCBI Entrez Gene (Gene ID: 6812)].

Description (Vector)

STXBP1 encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.

Gene ID

6812

Gene Name (eCommerce)

syntaxin binding protein 1

Gene Name (Vector)

syntaxin binding protein 1

Gene Symbol

STXBP1

HGNC ID

HGNC:11444

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1785

ORF Size (bp)

1785 bp

Protein Name (eCommerce)

Syntaxin-binding protein 1

RefSeq ID

NM_003165

RefSeq Synonyms

NM_003165, NM_001032221, BC015749,

Research Areas

Apoptosis,EGFR Signaling,Epilepsy,Insulin Signaling,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodevelopment,Signal Transduction

Research Areas (Faceted)

signal_transduction,cell_biology,neurobiology,signal_transduction,metabolism,cell_biology,neurobiology,developmental_biology

Species

human

Target Sentence

UniGene ID

Hs.288229

UniProt ID (eCommerce)

P61764

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.