human STIP1 shRNA silencing AAV

Name
AAV-h-STIP1-shRNA

Cat No
shAAV-224572

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human STIP1.

shAAV-224572

AAV-h-STIP1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human STIP1 (stress induced phosphoprotein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HEL-S-94n; HOP; IEF-SSP-3521; P60; STI1; STI1L

Description (Vector)

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 (PubMed 16100115)).(supplied by OMIM, Jul 2009)

Gene ID

10963

Gene Name (Vector)

stress induced phosphoprotein 1

Gene Symbol

STIP1

HGNC ID

HGNC:11387

ORF Size (aa)

1773

ORF Size (bp)

1773 bp

RefSeq ID

NM_006819

RefSeq Synonyms

NM_006819, NM_001282653, NM_001282652, BC039299, BC002987,

Species

human

UniGene ID

Hs.337295

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.