human SNF8 shRNA silencing AAV

Name
AAV-h-SNF8-shRNA

Cat No
shAAV-223829

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SNF8.

shAAV-223829

AAV-h-SNF8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SNF8 (SNF8, ESCRT-II complex subunit). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Dot3; EAP30; VPS22

Description (Vector)

SNF8, VPS25 (MIM 610907), and VPS36 (MIM 610903) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. SNF8, VPS25, and VPS36 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 (PubMed 15755741); Kamura et al., 2001 (PubMed 11278625)).(supplied by OMIM, Mar 2008)

Gene ID

11267

Gene Name (Vector)

SNF8, ESCRT-II complex subunit

Gene Symbol

SNF8

HGNC ID

HGNC:17028

ORF Size (aa)

777

RefSeq ID

NM_007241

RefSeq Synonyms

NM_007241, NM_001317194, NM_001317193, NM_001317192, BC038830, BC008976,

Species

human

UniGene ID

Hs.127249

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.