human SMPD1 shRNA silencing AAV

Name
AAV-h-SMPD1-shRNA

Cat No
shAAV-223767

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SMPD1.

shAAV-223767

AAV-h-SMPD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SMPD1 (sphingomyelin phosphodiesterase 1). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ASM; ASMASE; NPD

Description (Vector)

SMPD1 is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified.

Gene ID

6609

Gene Name (Vector)

sphingomyelin phosphodiesterase 1

Gene Symbol

SMPD1

HGNC ID

HGNC:11120

ORF Size (aa)

1095

RefSeq ID

NM_000543

RefSeq Synonyms

NM_001318088, NM_001318087, NM_001007593, NM_000543, BC041164,

Species

human

UniGene ID

Hs.498173

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.