human SMNDC1 shRNA silencing AAV

Name
AAV-h-SMNDC1-shRNA

Cat No
shAAV-223760

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SMNDC1.

shAAV-223760

AAV-h-SMNDC1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SMNDC1 (survival motor neuron domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

30 kDa splicing factor SMNrp; SMNR; SMN-related protein; SPF30; splicing factor 30, survival of motor neuron-related; survival motor neuron domain-containing protein 1; survival of motor neuron-related-splicing factor 30; TDRD16C; tudor domain containing 16C

Description (eCommerce)

SPF30 (splicing factor 30) is encoded by the SMNDC1 (survival motor neuron domain containing 1) gene and is a paralog of the SMN1 (survival motor neuron) protein. SPF30 has been identified as an essential component of the splicesome complex.

Description (Vector)

SMNDC1 is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. SMNDC1 is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene.

Gene ID

10285

Gene Name (eCommerce)

survival motor neuron domain containing 1

Gene Name (Vector)

survival motor neuron domain containing 1

Gene Symbol

SMNDC1

HGNC ID

HGNC:16900

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

717

Protein Name (eCommerce)

Survival of motor neuron-related-splicing factor 30

RefSeq ID

NM_005871

RefSeq Synonyms

NM_005871, BC011234,

Research Areas

Apoptosis,Gene Expression,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Spliceosome

Research Areas (Faceted)

cell_biology,genetics,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.632093

UniProt ID (eCommerce)

O75940

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.