human SMARCA2 shRNA silencing AAV

Name 
AAV-h-SMARCA2-shRNA
Cat No 
shAAV-223709
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SMARCA2.

shAAV-223709
AAV-h-SMARCA2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
ATP-dependent helicase SMARCA2; BAF190; BAF190B; brahma homolog; BRG1-associated factor 190B; BRM; global transcription activator homologous sequence; hBRM; hSNF2a; NCBRS; probable global transcription activator SNF2L2; protein brahma homolog; SNF2; SNF2/SWI2-like protein 2; SNF2-alpha; SNF2L2; SNF2LA; Sth1p; sucrose nonfermenting 2-like protein 2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; SWI2
Description (eCommerce)
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors (BAFs), have been identified as components of the human SWI/SNF-like chromatin-remodeling protein complexes. SMARCA2/Brm is an ATPase subunit of the SWI/SNF-A chromatin remodeling complex (BAF complex).
Description (Vector)
SMARCA2 is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.
Gene ID
6595
Gene Name (eCommerce)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Gene Name (Vector)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Gene Symbol
SMARCA2
HGNC ID
HGNC:11098
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4716
ORF Size (bp)
4716 bp
Protein Name (eCommerce)
Probable global transcription activator SNF2L2
RefSeq ID
NM_003070
RefSeq Synonyms
NM_139045, NM_003070, NM_001289400, NM_001289399, NM_001289398, NM_001289397, NM_001289396, BC156185,
Research Areas
Chromatin Remodeling,Cytoskeleton,Helicase Activity,Neurobiology,Neurodevelopment,Neurogenesis,Nuclear Receptor Coactivators,Transcription Factor/Regulator
Research Areas (Faceted)
neurobiology,developmental_biology,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
The SWI/SNF-related, matrix-associated, actin-dependent regulators of chromatin (SMARC), also called BRG1-associated factors (BAFs), have been identified as components of the human SWI/SNF-like chromatin-remodeling protein complexes. SMARCA2/Brm is an ATPase subunit of the SWI/SNF-A chromatin remodeling complex (BAF complex).
UniGene ID
Hs.298990
UniProt ID (eCommerce)
P51531

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.