human SMAD4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human SMAD4.
shAAV-223692
AAV-h-SMAD4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human SMAD4 (SMAD family member 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
deleted in pancreatic carcinoma locus 4; deletion target in pancreatic carcinoma 4; DPC4; hSMAD4; JIP; MAD homolog 4; MADH4; mothers against decapentaplegic homolog 4; mothers against decapentaplegic, Drosophila, homolog of, 4; Mothers against DPP homolog 4; MYHRS; SMAD 4; SMAD family member 4; SMAD, mothers against DPP homolog 4; Smad4
Description (eCommerce)
The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD4 forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. SMAD4 functions in the transforming growth factor-beta signaling pathway as well as the bone morphogenetic protein signaling pathway, regulating cell proliferation, angiogenesis, and increasing blood vessel hyperpermeability. [taken from NCBI Entrez Gene (Gene ID: 4089)].
Description (Vector)
SMAD4 encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Gene ID
4089
Gene Name (eCommerce)
SMAD family member 4
Gene Name (Vector)
SMAD family member 4
Gene Symbol
SMAD4
HGNC ID
HGNC:6770
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1659
ORF Size (bp)
1659 bp
Protein Name (eCommerce)
Mothers against decapentaplegic homolog 4
RefSeq ID
NM_005359
RefSeq Synonyms
NM_005359, BC002379,
Research Areas
Apoptosis,Autophagy,Breast Cancer,Cancer,Cardiac Development,Cardiology,Cardiovascular,Cell Cycle,Colorectal Cancer,DNA Damage/Repair,Gene Expression,Hippo Signaling,Host-Virus Interactions,Hypoxia,Leukemia,LKB1 Signaling,Neurobiology,Neurodevelopment,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. SMAD4 forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. SMAD4 functions in the transforming growth factor-beta signaling pathway as well as the bone morphogenetic protein signaling pathway, regulating cell proliferation, angiogenesis, and increasing blood vessel hyperpermeability. [taken from NCBI Entrez Gene (Gene ID: 4089)].
UniGene ID
Hs.75862
UniProt ID (eCommerce)
Q13485
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.