human SLC26A5 shRNA silencing AAV

Name
AAV-h-SLC26A5-shRNA

Cat No
shAAV-223306

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SLC26A5.

shAAV-223306

AAV-h-SLC26A5-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SLC26A5 (solute carrier family 26 member 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DFNB61; PRES

Description (Vector)

SLC26A5 encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

375611

Gene Name (Vector)

solute carrier family 26 member 5

Gene Symbol

SLC26A5

HGNC ID

HGNC:9359

ORF Size (aa)

2139

ORF Size (bp)

2139 bp

RefSeq ID

NM_198999

RefSeq Synonyms

NM_206885, NM_206884, NM_206883, NM_198999, NM_001321787, NM_001167962, BC100835, BC100833, BC100832,

Species

human

UniGene ID

Hs.585146

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.