human SLC1A1 shRNA silencing AAV

Name
AAV-h-SLC1A1-shRNA

Cat No
shAAV-223163

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SLC1A1.

shAAV-223163

AAV-h-SLC1A1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SLC1A1 (solute carrier family 1 member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

DCBXA; EAAC1; EAAT3; SCZD18

Description (Vector)

SLC1A1 encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect.

Gene ID

6505

Gene Name (Vector)

solute carrier family 1 member 1

Gene Symbol

SLC1A1

HGNC ID

HGNC:10939

ORF Size (aa)

1575

ORF Size (bp)

1575 bp

RefSeq ID

NM_004170

RefSeq Synonyms

NM_004170, BC033040,

Species

human

UniGene ID

Hs.444915

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.