human SLAMF6 shRNA silencing AAV

Name
AAV-h-SLAMF6-shRNA

Cat No
shAAV-223060

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SLAMF6.

shAAV-223060

AAV-h-SLAMF6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SLAMF6 (SLAM family member 6). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CD352; KALI; KALIb; Ly108; NTB-A; NTBA; SF2000

Description (Vector)

SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene ID

114836

Gene Name (Vector)

SLAM family member 6

Gene Symbol

SLAMF6

HGNC ID

HGNC:21392

ORF Size (aa)

996

RefSeq ID

NM_052931

RefSeq Synonyms

NM_052931, NM_001184716, NM_001184715, NM_001184714, BC114495, BC113893,

Species

human

UniGene ID

Hs.492348

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.