human SIK2 shRNA silencing AAV

Name 
AAV-h-SIK2-shRNA
Cat No 
shAAV-222999
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SIK2.

shAAV-222999
AAV-h-SIK2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SIK2 (salt inducible kinase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
LOH11CR1I; QIK; qin-induced kinase; Salt-inducible kinase 2; salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; serine/threonine-protein kinase SIK2; serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SNF1-like kinase 2; SNF1LK2
Description (eCommerce)
Salt-inducible protein kinase 2 (SIK2) phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Sik2 inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0K1].
Gene ID
23235
Gene Name (eCommerce)
salt inducible kinase 2
Gene Name (Vector)
salt inducible kinase 2
Gene Symbol
SIK2
HGNC ID
HGNC:21680
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2781
ORF Size (bp)
2781 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase SIK2
RefSeq ID
NM_015191
RefSeq Synonyms
NM_015191, BC117183, BC113459,
Research Areas
Golgi Apparatus,Insulin Signaling,Kinase/Phosphatase,LKB1 Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
Salt-inducible protein kinase 2 (SIK2) phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Sik2 inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9H0K1].
UniGene ID
Hs.269128
UniProt ID (eCommerce)
Q9H0K1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.