human SHC1 shRNA silencing AAV

Name
AAV-h-SHC1-shRNA

Cat No
shAAV-222930

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SHC1.

shAAV-222930

AAV-h-SHC1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SHC1 (SHC adaptor protein 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

SH2 domain protein C1; SHC; SHC (Src homology 2 domain containing) transforming protein 1; SHCA; SHC-transforming protein 1; SHC-transforming protein 3; SHC-transforming protein A; Src homology 2 domain-containing-transforming protein C1

Description (eCommerce)

Shc1 (src-homology domain protein C1) was originally identified as an SH2 containing proto-oncogene involved in growth factor signaling. Shc1 is functions as a signaling adapter that couples activated growth factor receptors to signaling pathways.

Description (Vector)

SHC1 encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Gene ID

6464

Gene Name (eCommerce)

SHC adaptor protein 1

Gene Name (Vector)

SHC adaptor protein 1

Gene Symbol

SHC1

HGNC ID

HGNC:10840

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1110

ORF Size (bp)

1110 bp

Protein Name (eCommerce)

SHC-transforming protein 1

RefSeq ID

NM_003029

RefSeq Synonyms

NM_183001, NM_003029, NM_001202859, NM_001130041, NM_001130040, BC033925, BC014158,

Research Areas

Aging,Angiogenesis,Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Breast Cancer,Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Cytokine Signaling,Cytoskeleton,DNA Damage/Repair,DNA Replication,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,Glioma,HGF Signaling,Host-Virus Interactions,Hypoxia,IGF-1 Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Leptin Signaling,Leukemia,MAPK Signaling,MicroRNAs in Cancer,Mitochondrion,Neurobiology,Neurodevelopment,NGF Signaling,PDGF Signaling,Prolactin Signaling,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TPO Signaling,TRKA Signaling,VEGF Signaling

Research Areas (Faceted)

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation

Species

human

Target Sentence

UniGene ID

Hs.433795

UniProt ID (eCommerce)

P29353

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.