human SFRS7 shRNA silencing AAV

Name 
AAV-h-SFRS7-shRNA
Cat No 
shAAV-222812
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SRSF7.

shAAV-222812
AAV-h-SFRS7-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SRSF7 (serine and arginine rich splicing factor 7). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
9G8; AAG3; aging-associated protein 3; serine/arginine-rich splicing factor 7; SFRS7; splicing factor 9G8; Splicing factor, arginine/serine-rich 7; splicing factor, arginine/serine-rich 7, 35kDa; SR splicing factor 7
Description (eCommerce)
Serine/arginine-rich splicing factor 7 (SRSF7) is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation [taken from NCBI Entrez Gene (Gene ID: 6432)].
Description (Vector)
SRSF7 is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
6432
Gene Name (eCommerce)
serine and arginine rich splicing factor 7
Gene Name (Vector)
serine and arginine rich splicing factor 7
Gene Symbol
SRSF7
HGNC ID
HGNC:10789
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
717
Protein Name (eCommerce)
Serine/arginine-rich splicing factor 7
RefSeq ID
NM_001031684
RefSeq Synonyms
NM_001195446, NM_001031684, BC022328, BC017908, BC017369, BC000997,
Research Areas
Gene Expression,Host-Virus Interactions,mRNA Processing,mRNA Splicing,mRNA Transport,Neurobiology,RNA Binding,RNA Processing,RNA Transport,Spliceosome,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
genetics,transcription_translation,infectious_disease,cell_biology,neurobiology,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Serine/arginine-rich splicing factor 7 (SRSF7) is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation [taken from NCBI Entrez Gene (Gene ID: 6432)].
UniGene ID
Hs.309090
UniProt ID (eCommerce)
Q16629

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.