human SERPING1 shRNA silencing AAV

Name
AAV-h-SERPING1-shRNA

Cat No
shAAV-222710

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SERPING1.

shAAV-222710

AAV-h-SERPING1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SERPING1 (serpin family G member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C1IN; C1INH; C1NH; HAE1; HAE2

Description (Vector)

SERPING1 encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform.

Gene ID

710

Gene Name (Vector)

serpin family G member 1

Gene Symbol

SERPING1

HGNC ID

HGNC:1228

ORF Size (aa)

1503

ORF Size (bp)

1503 bp

RefSeq ID

NM_000062

RefSeq Synonyms

NM_001032295, NM_000062, BC011171,

Species

human

UniGene ID

Hs.384598

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.