human SERPINB6 shRNA silencing AAV

Name 
AAV-h-SERPINB6-shRNA
Cat No 
shAAV-222693
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human SERPINB6.

shAAV-222693
AAV-h-SERPINB6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SERPINB6 (serpin family B member 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAP; cytoplasmic antiproteinase; DFNB91; MSTP057; Peptidase inhibitor 6; PI6; PI-6; Placental thrombin inhibitor; protease inhibitor 6 (placental thrombin inhibitor); PTI; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6; serpin B6; serpin peptidase inhibitor, clade B (ovalbumin), member 6; SPI3
Description (eCommerce)
SERPINB6 is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. SERPINB6 was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear [taken from NCBI Entrez Gene (Gene ID: 5269)].
Description (Vector)
SERPINB6 is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene.
Gene ID
5269
Gene Name (eCommerce)
serpin family B member 6
Gene Name (Vector)
serpin family B member 6
Gene Symbol
SERPINB6
HGNC ID
HGNC:8950
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1131
ORF Size (bp)
1131 bp
Protein Name (eCommerce)
Serpin B6
RefSeq ID
NM_004568
RefSeq Synonyms
NM_004568, NM_001297700, NM_001297699, NM_001271825, NM_001271824, NM_001271823, NM_001271822, NM_001195291, BC098564, BC001394,
Research Areas
Neurobiology
Research Areas (Faceted)
neurobiology
Species
human
Target Sentence
SERPINB6 is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. SERPINB6 was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear [taken from NCBI Entrez Gene (Gene ID: 5269)].
UniGene ID
Hs.519523
UniProt ID (eCommerce)
P35237

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.