human SEMA3E shRNA silencing AAV

Name
AAV-h-SEMA3E-shRNA

Cat No
shAAV-222542

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human SEMA3E.

shAAV-222542

AAV-h-SEMA3E-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SEMA3E (semaphorin 3E). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

coll-5; M-SEMAH; M-SemaK; SEMAH

Description (Vector)

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene encodes a class 3 semaphorin. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene ID

9723

Gene Name (Vector)

semaphorin 3E

Gene Symbol

SEMA3E

HGNC ID

HGNC:10727

ORF Size (aa)

2328

ORF Size (bp)

2328 bp

RefSeq ID

NM_001178129

RefSeq Synonyms

NM_012431, NM_001178129, BC152458, BC144338, BC140706,

Species

human

UniGene ID

Hs.528721

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.