human SAP18 shRNA silencing AAV

Name
AAV-h-SAP18-shRNA

Cat No
shAAV-222234

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human SAP18.

shAAV-222234

AAV-h-SAP18-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human SAP18 (Sin3A associated protein 18). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

2HOR0202; SAP18P

Description (Vector)

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.

Gene ID

10284

Gene Name (Vector)

Sin3A associated protein 18

Gene Symbol

SAP18

HGNC ID

HGNC:10530

ORF Size (aa)

462

RefSeq ID

NM_005870

RefSeq Synonyms

NM_005870, BC030836,

Species

human

UniGene ID

Hs.524899

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.