human RTN3 shRNA silencing AAV

Cat. No: shAAV-222089

Availability: 4-5 weeks

Name: AAV-h-RTN3-shRNA

This is an AAV expressing shRNA for silencing of Human RTN3.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RTN3
Gene Name: reticulon 3
Gene ID: 10313
Gene Synonyms: ASYIP; HAP; NSPL2; NSPLII; RTN3-A1
ORF Size: 3039 bp
RefSeq#: NM_006054
Gene Description: RTN3 belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12.
UniGene ID: Hs.473761
HGNC ID: HGNC:10469