human RTN2 shRNA silencing AAV

Name
AAV-h-RTN2-shRNA

Cat No
shAAV-222088

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human RTN2.

shAAV-222088

AAV-h-RTN2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RTN2 (reticulon 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

NSP2; NSPL1; NSPLI; SPG12

Description (Vector)

RTN2 belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12.

Gene ID

6253

Gene Name (Vector)

reticulon 2

Gene Symbol

RTN2

HGNC ID

HGNC:10468

ORF Size (aa)

1638

ORF Size (bp)

1638 bp

RefSeq ID

NM_005619

RefSeq Synonyms

NM_206901, NM_206900, NM_005619, BC073874, BC014244,

Species

human

UniGene ID

Hs.47517

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.