human RRN3 shRNA silencing AAV

Name
AAV-h-RRN3-shRNA

Cat No
shAAV-222008

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RRN3.

shAAV-222008

AAV-h-RRN3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RRN3 (RRN3 homolog, RNA polymerase I transcription factor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

A-270G1.2; RNA polymerase I-specific transcription initiation factor RRN3; RRN3 RNA polymerase I transcription factor homolog; TIFIA; TIF-IA; transcription initiation factor IA; transcription initiation factor TIF-IA

Description (eCommerce)

Transcription initiation factor IA (TIF-IA) is encoded by the RRN3 gene which was identified and cloned due to its homology with the yeast Rrn3p gene. TIF-IA has been shown to recruit initiation-competent RNA Polymerase I to rRNA promoters.

Gene ID

54700

Gene Name (eCommerce)

RRN3 homolog, RNA polymerase I transcription factor

Gene Name (Vector)

RRN3 homolog, RNA polymerase I transcription factor

Gene Symbol

RRN3

HGNC ID

HGNC:30346

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1956

ORF Size (bp)

1956 bp

Protein Name (eCommerce)

RNA polymerase I-specific transcription initiation factor RRN3

RefSeq ID

NM_018427

RefSeq Synonyms

NM_018427, NM_001301064, BC132690, BC132688,

Research Areas

Apoptosis,Gene Expression,mTOR Signaling,RNA Binding,Signal Transduction,Transcription Factor/Regulator

Research Areas (Faceted)

cell_biology,signal_transduction,transcription_translation

Species

human

Target Sentence

Transcription initiation factor IA (TIF-IA) is encoded by the RRN3 gene which was identified and cloned due to its homology with the yeast Rrn3p gene. TIF-IA has been shown to recruit initiation-competent RNA Polymerase I to rRNA promoters.

UniGene ID

Hs.460078

UniProt ID (eCommerce)

Q9NYV6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.