human RPSA shRNA silencing AAV

37 kDa laminin receptor; 37 kDa laminin receptor precursor; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; colon carcinoma laminin-binding protein; ICAS; LAMBR; Laminin receptor 1; laminin receptor 1 (67kD, ribosomal protein SA); laminin-binding protein precursor p40; lamR; LAMR1; LBP; LBP/p40; LRP; LRP/LR; multidrug resistance-associated protein MGr1-Ag; NEM/1CHD4; p40; SA; small ribosomal subunit protein uS2

RPSA is required for the assembly and/or stability of the 40S ribosomal subunit. RPSA is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. RPSA also functions as a cell surface receptor for laminin and plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. RPSA may play a role in cell fate determination and tissue morphogenesis. It acts as a PPP1R16B-dependent substrate of PPP1CA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P08865].

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

3921

ribosomal protein SA

ribosomal protein SA

RPSA

HGNC:6502

9606.0

888

888 bp

40S ribosomal protein SA

NM_002295

NM_002295, NM_001304288, NM_001012321, BC107567, BC073863, BC071970, BC071969, BC071968, BC071693, BC070263, BC068062, BC066941, BC062714, BC053370, BC050688, BC034537, BC013827, BC010418, BC008867, BC005391,

Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,mRNA Binding,RNA Processing,Translational Control

cell_biology,genetics,infectious_disease,metabolism,transcription_translation

human

RPSA is required for the assembly and/or stability of the 40S ribosomal subunit. RPSA is required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. RPSA also functions as a cell surface receptor for laminin and plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. RPSA may play a role in cell fate determination and tissue morphogenesis. It acts as a PPP1R16B-dependent substrate of PPP1CA [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P08865].

Hs.449909

P08865