human RPS8 shRNA silencing AAV

Name 
AAV-h-RPS8-shRNA
Cat No 
shAAV-221954
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RPS8.

shAAV-221954
AAV-h-RPS8-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RPS8 (ribosomal protein S8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
40S ribosomal protein S8; OK/SW-cl.83; S8; small ribosomal subunit protein eS8
Description (eCommerce)
Ribosomal Protein S8/RPS8 has been Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P62241].
Description (Vector)
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Gene ID
6202
Gene Name (eCommerce)
ribosomal protein S8
Gene Name (Vector)
ribosomal protein S8
Gene Symbol
RPS8
HGNC ID
HGNC:10441
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
627
Protein Name (eCommerce)
40S ribosomal protein S8
RefSeq ID
NM_001012
RefSeq Synonyms
NM_001012, BC070875,
Research Areas
Gene Expression,Host-Virus Interactions,Metabolism/Metabolic Process,mRNA Binding,RNA Processing,Translational Control
Research Areas (Faceted)
cell_biology,genetics,infectious_disease,metabolism,transcription_translation
Species
human
Target Sentence
Ribosomal Protein S8/RPS8 has been Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P62241].
UniGene ID
Hs.512675
UniProt ID (eCommerce)
P62241

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.